HuagongsheHuagongshe Chemistry Print Report · For research reference only
Hydrochloric Acid → 2-amino-5-methylthio-N-[(1-diphenylmethylpiperidin-4-yl)methyl]benzamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | Water | HCID 962 | — |
| Reactant | 5-methylthio-2-nitro-N-[(1-diphenylmethylpiperidin-4-yl)methyl]benzamide | HCID 67596805 | — |
| Catalyst | Iron | HCID 23925 | — |
| Solvent | Ethanol | HCID 702 | — |
| Product | 2-amino-5-methylthio-N-[(1-diphenylmethylpiperidin-4-yl)methyl]benzamide | HCID 67594739 | — |
Reaction Steps
Step 2): A mixture of 5-methylthio-2-nitro-N-[(1-diphenylmethylpiperidin-4-yl)methyl]benzamide (500 mg, 1.05 mmol), Fe powder (587 mg, 1.05 mmol), conc. HCl (0.05 ml), H2O (8 ml) and EtOH (35 ml) was refluxed overnight. The insoluble precipitates were filtered off and then the filtrate was evaporated to give 2-amino-5-methylthio-N-[(1-diphenylmethylpiperidin-4-yl)methyl]benzamide as colorless powder, 450 mg (96%): mp 156°-157° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05872115 |
| Source dataset | uspto-grants-1999_02 |
| ORD ID | ord-5d559bfd3de84d1fb42389fff5bea64a |
| Source note | uspto-grants-1999_02 |