HCID 53943442, compound → HCID 54122730, compound

HRID 362919Notes

Reaction equation

HRID 362919 reaction equation
[CH3:1][N:2]([CH3:34])[C:3]1[CH:30]=[CH:29][CH:28]=[C:27]([N+:31]([O-])=O)[C:4]=1[C:5]([NH:7][CH:8]1[CH2:13][CH2:12][N:11]([CH:14]([C:21]2[CH:26]=[CH:25][CH:24]=[CH:23][CH:22]=2)[C:15]2[CH:20]=[CH:19][CH:18]=[CH:17][CH:16]=2)[CH2:10][CH2:9]1)=[O:6]>[Ni].CCO>[NH2:31][C:27]1[CH:28]=[CH:29][CH:30]=[C:3]([N:2]([CH3:34])[CH3:1])[C:4]=1[C:5]([NH:7][CH:8]1[CH2:13][CH2:12][N:11]([CH:14]([C:15]2[CH:16]=[CH:17][CH:18]=[CH:19][CH:20]=2)[C:21]2[CH:26]=[CH:25][CH:24]=[CH:23][CH:22]=2)[CH2:10][CH2:9]1)=[O:6]

Participants

4

Reactant 1

HCID 53943442HCID 53943442, compound

Product 1

HCID 54122730HCID 54122730, compound

Reagents, catalysts & solvents 2

HCID 935NickelCatalystHCID 702EthanolSolvent

Procedure

Step 4): A mixture of 2-dimethylamino-6-nitro-N-(1-diphenylmethylpiperidin-4-yl)benzamide (1.60 g, 3.5 mmol) and Raney Nickel in EtOH (75 ml) was stirred under H2 at room temperature for 4 hours. The mixture was filtered, and the filtrate was concentrated under vacuum to obtain 2-amino-6-dimethylamino-N-(1-diphenylmethylpiperidin-4-yl) benzamide. 1.42 g (95%).

Workup

  1. filtrationThe mixture was filtered
  2. concentrationthe filtrate was concentrated under vacuum

Sources & evidence

ORD record
ord-6334c161cd8a476e9d34f4bfcf4b8aef
Source dataset
uspto-grants-1999_02
Patent number
US05872115

Reaction notes

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