HCID 53904510, compound → HCID 53783949, compound

Participants

Reaction Steps

Step 1): 10% Pd/C was added to a solution of the N-(1-benzylpiperidin-4yl)-2-(N'-n-heptylureido)benzamide (1.4 g, 3.1 mmol) obtained in Example 41 in methanol (25 ml) under nitrogen. The mixture was shaken under 50 psi hydrogen pressure for 5 hours, and then filtered under nitrogen. The filtrate was concentrated. The residue was purified by column chromatography on silica gel (50% methanol and 0.8% NH4OH in dichloromethane) to give N-(piperidin-4-yl)-2-(N'-n-heptylureido)benzamide: 48.4%: mp 159° C.

Provenance & Evidence