1-(Diphenylmethyl)-4-piperidinamine → HCID 54099729, compound

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Reaction Steps

A mixture of 2-n-heptylamino-4H-3,1-benzoxazin-4-one (3.0 g, 10 mmol) and 4-amino-1-diphenylmethylpiperidine (3.0 g, 10 mmol) in toluene (20 ml) was refluxed for 3 hours and then concentrated. The residue was purified by column chromatography on silica gel (20% ethyl acetate in hexane) to give 2-(N'-n-heptylureido)-N-(1-diphenylmethylpiperidin-4-yl)benzamide (2.3 g, 40%): mp 182° C.; 1H NMR (CDCl3)ppm: 0.87 (3H, t), 1.27-1.30 (8H, m), 1.47-1.67 (4H, m), 1.95-2.12 (4H, m), 2.84 (2H, d), 3.24 (2H, q), 3.90-3.94 (1H, m), 4.26 (1H, s), 4.56 (1H, t), 6.09 (1H, d), 6.92-6.98 (1H, m), 7.16-7.44 (12H, m), 8.41 (1H, d), 10.26 (1H, s).

Provenance & Evidence