HCID 54478803, compound → HCID 54111482, compound

Participants

Reaction Conditions

Reaction Steps

Step 1): A mixture of 2-(N'-n-heptylureido)-N-(pyridin-3-yl)benzamide obtained in the Example 34 (5.0 g, 14 mmol) and PtO2 in acetic acid (70 ml) was stirred at 40° C. under hydrogen atmosphere (50 psi) for 17 hours and then filtered. The filtrate was neutralized with 30% NaOH solution, extracted with ethyl acetate and washed with saturated NaHCO3 solution. The organic layer was dried (MgSO4) and concentrated. The residue was purified by column chromatography on silica gel (20% methanol and 0.8% NH4OH in dichloromethane) to give 2-(N'-n-heptylureido)-N-(piperidin-3-yl)benzamide (83.8%): mp 165° C.

Provenance & Evidence