HuagongsheHuagongshe Chemistry Print Report · For research reference only
5-diethylamino-2-nitro-N-[(1-diphenylmethylpiperidin-4-yl)methyl]benzamide → 2-amino-5-diethylamino-N-[(1-diphenylmethylpiperidin-4-yl)methyl]benzamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 5-diethylamino-2-nitro-N-[(1-diphenylmethylpiperidin-4-yl)methyl]benzamide | HCID 67596772 | — |
| Catalyst | Adams' catalyst | HCID 345198 | — |
| Product | 2-amino-5-diethylamino-N-[(1-diphenylmethylpiperidin-4-yl)methyl]benzamide | HCID 67595875 | — |
Reaction Steps
Step 2): To a solution of 5-diethylamino-2-nitro-N-[(1-diphenylmethylpiperidin-4-yl)methyl]benzamide (1.0 g, 1.99 mmol) was added PtO2 (30 mg). The solution was stirred under H2 atmosphere (3 kg/cm2) for 3 hours. The catalysts were filtered off and the filtrate was evaporated to give 2-amino-5-diethylamino-N-[(1-diphenylmethylpiperidin-4-yl)methyl]benzamide, 930 mg(100%): mp 161°-163° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05872115 |
| Source dataset | uspto-grants-1999_02 |
| ORD ID | ord-976ecc18339646d282c8747f0d7f3dd4 |
| Source note | uspto-grants-1999_02 |