Acetyl chloride → HCID 19939421, compound

Participants

Reaction Steps

The reaction of 2-(5-amino-2-chlorophenyl)-5-n-butyl-4-[[2'-(N-t-butylsulfamoyl)-3-fluoro-5'-n-propylbiphenyl-4-yl]methyl]-2,4-dihydro-3H-1,2,4-triazol-3-one (from Step C) with acetyl chloride was carried out according to the procedure of Example 69, affording an 88% yield of the title compound as a cream-colored solid, mp 125°-128° C.; satisfactory purity by TLC in 95:5 CH2Cl2 --MeOH; mass spectrum (FAB) m/e 676 (M+Li)+.

Provenance & Evidence