HuagongsheHuagongshe Chemistry Print Report · For research reference only
4-Bromo-2-fluorotoluene → 3-Fluoro-4-methyl-2'-(N-t-butylsulfamoyl)biphenyl
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 4-Bromo-2-fluorotoluene | HCID 171040 | — |
| Reactant | Boronic acid, B-(2-(((1,1-dimethylethyl)amino)sulfonyl)phenyl)- | HCID 4997616 | — |
| Catalyst | Palladium | HCID 23938 | — |
| Product | 3-Fluoro-4-methyl-2'-(N-t-butylsulfamoyl)biphenyl | HCID 10087424 | 92% |
Reaction Steps
The palladium(0)-catalyzed coupling of 4-bromo-2-fluorotoluene with 2-(N-t-butylsulfamoyl)phenylboronic acid was carried out according to the procedure of Example 76, Step F. Purification of the crude product by flash chromatography (elution with hexane-EtOAc) gave a 92% yield of the title compound as an off-white foam (TLC in 4:1 hexane-EtOAc); mass spectrum (FAB) m/e 322 (M+1)+.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05411980 |
| Source dataset | uspto-grants-1995_05 |
| ORD ID | ord-3d6b6f4d22314c4ab5ae4e244b8af097 |
| Source note | uspto-grants-1995_05 |