Ethanol hydrochloride → 1-(1-Naphthyl)-2-((piperazin-2-yl)methoxy]ethanol dihydrochloride

HRID 362972Notes

Reaction equation

HRID 362972 reaction equation
C([N:3]1[CH2:8][CH2:7][N:6](C=O)[CH2:5][CH:4]1[CH2:11][O:12][CH2:13][CH:14]([C:16]1[C:25]2[C:20](=[CH:21][CH:22]=[CH:23][CH:24]=2)[CH:19]=[CH:18][CH:17]=1)[OH:15])=O.[ClH:26].C(O)C>CO>[ClH:26].[ClH:26].[C:16]1([CH:14]([OH:15])[CH2:13][O:12][CH2:11][CH:4]2[CH2:5][NH:6][CH2:7][CH2:8][NH:3]2)[C:25]2[C:20](=[CH:21][CH:22]=[CH:23][CH:24]=2)[CH:19]=[CH:18][CH:17]=1

Participants

4

Reactant 2

HCID 21887872Ethanol hydrochlorideHCID 536559232-[(1,4-Diformylpiperazin-2-yl)methoxy]-1-(1-naphthyl)ethanol

Product 1

HCID 676622091-(1-Naphthyl)-2-((piperazin-2-yl)methoxy]ethanol dihydrochloride

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

In 1.5 ml of methanol was dissolved 250 mg of 2-[(1,4-diformylpiperazin-2-yl)methoxy]-1-(1-naphthyl)ethanol. To the solution was added 1.5 ml of a 5N dry hydrogen chloride-ethanol solution. The mixture was allowed to stand at room temperature overnight. The resulting crystals were collected by filtration, washed with ethanol, and dried to obtain 180 mg of 1-(1-naphthyl)-2-((piperazin-2-yl)methoxy]ethanol dihydrochloride (compound No. 274).

Workup

  1. filtrationThe resulting crystals were collected by filtration
  2. washwashed with ethanol
  3. customdried

Sources & evidence

ORD record
ord-7461665d8a8d4cd098847ed13dc39153
Source dataset
uspto-grants-1999_02
Patent number
US05872117

Reaction notes

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