反应详情

To a solution of 2-methyl-3-nitro-phenol (3.0 g, 19.6 mmol), triphenylphosphine (7.2 g, 27.4 mmol), and chloroethanol (1.89 g, 23.5 mmol) in anhydrous tetrahydrofuran (70 mL) was slowly added a solution of diethylazidodicarboxylate (4.78 g, 27.4 mmol). After 1 h the reaction was complete and the solvent was removed and the residue dissolved in 1:1 ethyl acetate-hexanes (150 mL). After 30 min the solid triphenylphosphine oxide was filtered and the solvent again removed. The crude product was purified by chromatography (20% ethyl acetate-hexanes) to afford 4.2 g (100%) of a light yellow solid: mp 58°-59° C.

1. customthe solvent was removed
2. dissolutionthe residue dissolved in 1:1 ethyl acetate-hexanes (150 mL)
3. filtrationAfter 30 min the solid triphenylphosphine oxide was filtered
4. customthe solvent again removed
5. customThe crude product was purified by chromatography (20% ethyl acetate-hexanes)