Carbon tetrabromide → HCID 54080281, compound

Participants

Reaction Steps

A solution of 1-4 (3.6 g, 12 mmol), triphenyl phosphine (3.1 g, 11.8 mmol) in THF (100 ml) was treated with carbon tetrabromide (3.9 g, 11.8 mmol). After 12 h additional triphenylphosphine (3.1 g, 11.8 mmol) was added and the mixture allowed to stir at room temperature overnight. Some triphenyl phosphine oxide was then filtered off and the filtrate concentrated to dryness. The residue was chromatographed on a Still column (70 mm) and the product eluted with 5% EtOAc-hexane to yield 1-5.

Provenance & Evidence