Ethanol → 2-[5-Amino-2-(trifluoromethyl)phenyl]-5-n-butyl-4-[[2'-(N-t-butylsulfamoyl)-3-fluorobiphenyl-4-yl]methyl]-2,4-dihydro-3H-1,2,4-triazol-3-one

Participants

Role	Name	HCID	Charge
Reactant	Ethanol	HCID 702	—
Reactant	5-n-Butyl-4-[[2'-(N-t-butylsulfamoyl)-3-fluorobiphenyl-4-yl]methyl]-2,4-dihydro-2-[5-nitro-2-(trifluoromethyl)phenyl]-3H-1,2,4-triazol-3-one	HCID 11764838	—
Solvent	Ethyl Acetate	HCID 8857	—
Product	2-[5-Amino-2-(trifluoromethyl)phenyl]-5-n-butyl-4-[[2'-(N-t-butylsulfamoyl)-3-fluorobiphenyl-4-yl]methyl]-2,4-dihydro-3H-1,2,4-triazol-3-one	HCID 11758565	91%

Reaction Steps

Hydrogenation of 5-n-butyl-4-[[2'-(N-t-butylsulfamoyl)-3-fluoro-biphenyl-4-yl]methyl]-2,4-dihydro-2-[5-nitro-2-(trifluoromethyl)phenyl]-3H-1,2,4-triazol-3-one (from Example 84, Step D) was carried out according to the procedure of Example 75, Step D, except that a 4:1 ratio of ethanol and ethyl acetate was used as solvent. The title compound was obtained in 91% yield oas an off-white foam, suitable for use without further purification; nearly homogeneous by TLC in 95:5 CH2Cl2 --MeOH; mass spectrum (FAB) m/e 626 (M+Li)+.

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US05411980
Source dataset	uspto-grants-1995_05
ORD ID	ord-1941268571b640449e5f56ae360f39e1
Source note	uspto-grants-1995_05