4-Aminopyridine → HCID 54465861, compound

Participants

Reaction Conditions

Reaction Steps

To a solution of 23-6 (270 mg, 1.0 mmol) in 3.6 mL of CH2Cl2 was added 0.13 mL (1.5 mmol) of oxalyl chloride. The resulting solution was stirred for 1 h, cooled to 0° C. and treated with 380 mg (4.0 mmol) of 4-aminopyridine. Stirring was continued for 1 h before the heterogeneous mixture was diluted with CH2Cl2 and quenched with sat'd NaHCO3. The organic extract was washed with water, brine and dried over Na2SO4. Evaporation of the solvent and column chromatography (3:1 EtOAc/Hexane) afforded product 23-7.

Provenance & Evidence