反应详情

Then, 16 g of 2-ethyl-6-methylphenol was dissolved in 200 ml of chloroform, followed by stirring at 0° C., to which 56.6 g of tetrabutylammonium tribromide was added in small portions. After stirring at room temperature for 1 hour, the solvent was removed by distillation under reduced pressure, and the residue was dissolved in 300 ml of diethyl ether. The solution was successively washed with 10% hydrochloric acid and water, dried with anhydrous magnesium sulfate, and concentrated to obtain a crude product. The crude product was subjected to silica gel chromatography, which afforded 23 g of 4-bromo-2-ethyl-6-methylphenol (92% yield).

1. additionwas added in small portions
2. customthe solvent was removed by distillation under reduced pressure
3. dissolutionthe residue was dissolved in 300 ml of diethyl ether
4. washThe solution was successively washed with 10% hydrochloric acid and water
5. dry with materialdried with anhydrous magnesium sulfate
6. concentrationconcentrated
7. customto obtain a crude product