反应详情

Then, 0.85 g of 4-(2-chlorobenzyloxy)-3,5-dichlorophenoxyacetaldehyde diethyl acetal was dissolved in 10 ml of acetic acid, to which 1 ml of concentrated hydrochloric acid was added dropwise, while stirring under ice cooling. After stirring under ice cooling for 2 hours, the reaction mixture was poured into ice water, and extracted twice with diethyl ether. The combined ether layer was washed with water, dried with anhydrous magnesium sulfate, followed by removal of the solvent by distillation under reduced pressure, which afforded 0.70 g of 4-(2-chlorobenzyloxy)-3,5-dichlorophenoxyacetaldehyde in crude form.

1. additionwas added dropwise
2. stirringAfter stirring under ice cooling for 2 hours
3. extractionextracted twice with diethyl ether
4. washThe combined ether layer was washed with water
5. dry with materialdried with anhydrous magnesium sulfate
6. customfollowed by removal of the solvent by distillation under reduced pressure, which