関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|
| 反応物 | Benzoyl chloride | HCID 7412 | — |
| 反応物 | Triethylamine | HCID 8471 | — |
| 反応物 | 4-Benzyloxy-3-chloro-5-methylphenol | HCID 18504631 | — |
| 溶媒 | Chloroform | HCID 6212 | — |
| 生成物 | 4-Benzyloxy-3-chloro-5-methyl-1-benzoyloxybenzene | HCID 18504554 | 90.6% |
反応手順
To a solution of 27.3 g of 4-benzyloxy-3-chloro-5-methylphenol dissolved in 250 ml of chloroform and stirred at 0° C. were added 15.4 g of benzoyl chloride and then 13.3 g of triethylamine. After stirring at room temperature for 2 hours, the chloroform layer was washed with water, dried with anhydrous magnesium sulfate, and concentrated. The residue was subjected to silica gel chromatography, which afforded 35 g of 4-benzyloxy-3-chloro-5-methyl-1-benzoyloxybenzene (90% yield).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 特許番号 | US05872137 |
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| 出典データセット | uspto-grants-1999_02 |
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| ORD ID | ord-8eb169f2080549fd9d816b7da9a110ca |
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| 出典メモ | uspto-grants-1999_02 |
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