反应详情

A reaction vessel was charged with 11.6 g of 3,5-dichloro-4-(3-benzoyloxypropyloxy)-1-(3,3-dichloro-2-propenyloxy)benzene, 15.2 g of 10% aqueous potassium hydroxide solution and 300 ml of methanol. After stirring at room temperature for 24 hours, and the reaction mixture was concentrated. The concentrate was poured into water, and extracted twice with 150 ml of diethyl ether. The combined ether layer was washed with water, dried with anhydrous magnesium sulfate, and concentrated to obtain a crude product. The crude product was subjected to silica gel chromatography, which afforded 7.41 g of 3-(2,6-dichloro-4-(3,3-dichloro-2-propenyloxy)phenoxy)-1-propyl alcohol (83%o yield), m.p. 56.6° C.

1. concentrationthe reaction mixture was concentrated
2. additionThe concentrate was poured into water
3. extractionextracted twice with 150 ml of diethyl ether
4. washThe combined ether layer was washed with water
5. dry with materialdried with anhydrous magnesium sulfate
6. concentrationconcentrated
7. customto obtain a crude product