HuagongsheHuagongshe Chemistry Print Report · For research reference only
Azobisisobutyronitrile → 3-Phenyl-2-chloro-6-bromomethylpyridine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Azobisisobutyronitrile | HCID 6547 | — |
| Reactant | N-bromobutanimide | HCID 67184 | — |
| Reactant | 2-Chloro-6-methyl-3-phenylpyridine | HCID 14980530 | — |
| Solvent | Carbon Tetrachloride | HCID 5943 | — |
| Product | 3-Phenyl-2-chloro-6-bromomethylpyridine | HCID 54340451 | — |
Reaction Steps
A solution of 3-Phenyl-2-chloro-6-methylpyridine (0.094 g, 0.462 mmol), NBS (0.086 g, 0.485 mmol) and AIBN (0.008 g, 0.046mmol) in CCl4 (3 mL) were heated at reflux for 2 hours. The solvent was evaporated and the residue chromatographed (Silica gel, 100% CH2Cl2 to afford the title compound.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05872136 |
| Source dataset | uspto-grants-1999_02 |
| ORD ID | ord-6d7d8198179a4f568c3b52dbfa301801 |
| Source note | uspto-grants-1999_02 |