HuagongsheHuagongshe Chemistry Print Report · For research reference only
Sodium Carbonate → 5-Bromo-2-[4-(phenylmethoxy)phenyl]pyrimidine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Sodium Carbonate | HCID 10340 | — |
| Reactant | 4-Benzyloxy-phenylboronic acid | HCID 2734314 | — |
| Reactant | 2,5-Dibromopyrimidine | HCID 10955588 | — |
| Catalyst | Palladium | HCID 23938 | — |
| Solvent | Ethanol | HCID 702 | — |
| Solvent | Water | HCID 962 | — |
| Solvent | Toluene | HCID 1140 | — |
| Product | 5-Bromo-2-[4-(phenylmethoxy)phenyl]pyrimidine | HCID 564028 | — |
Reaction Steps
A solution of 104 g of 2,5-dibromopyrimidine, 100 g of 4-benzoxyphenylboronic acid, 4.75 g of Pd (10% on activated charcoal), 4.5 g of triphenylphosphene and 93 g of sodium carbonate in 1 l of toluene, 0.5 l of ethanol and 0.3 l of water is heated at 80° C. for 24 hours. After filtration, the organic phase is separated off and evaporated to dryness in vacuo. The residue is recrystallized from acetonitrile: 83 g of solids of melting point 153°-155° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05872301 |
| Source dataset | uspto-grants-1999_02 |
| ORD ID | ord-5a8242bfa432484d87da14a66bb1736e |
| Source note | uspto-grants-1999_02 |