反应详情

A mixture of 18.72 g (0.10 mol) of 4-methoxybenzenesulfonamide, 24.75 g (0.10 mol) of 4-(2-bromoethyl)benzoyl chloride and 200 ml of toluene was stirred and heated to reflux at which time solution was achieved. The solution was heated at reflux for 16.5 hrs. The vapors emitted from the condenser were acidic during reaction. After this time, the solution was cooled and concentrated to an oil. The oil was dissolved in 3:7 heptane:toluene and cooled. Solid crystallized and was collected, washed with ligroine and dried.

1. temperatureheated
2. temperatureto reflux at which time solution
3. temperatureThe solution was heated
4. temperatureat reflux for 16.5 hrs
5. customwere acidic during reaction
6. temperatureAfter this time, the solution was cooled
7. concentrationconcentrated to an oil
8. dissolutionThe oil was dissolved in 3:7 heptane
9. temperaturetoluene and cooled
10. customSolid crystallized
11. customwas collected
12. washwashed with ligroine
13. customdried