Benzyl Bromide → HCID 53922389, compound

Participants

Reaction Steps

A mixture of the title compound of Step D (0.5 g, 2.46 mmol), K2CO3 (1.02 g, 7.38 mmol), benzyl bromide (0.463 g, 2.71 mmol) and TBAB (79 mg) in DMF (5 mL) was stirred at room temperature for 48 h. After the reaction was complete, the reaction mixture was poured into an H2O/ethyl acetate mixture (10/100 mL). The organic phase was separated, dried and concentrated to give the title compound of Step E as a brown solid (0.76 g). 1H NMR (CDCl3, 300 MHz): δ 7.32 (m,6H, aromatic) 6.72 (d,1H, 11 Hz), 6.34 (d,1H, 8 Hz), 4.82 (s,2H), 4.69 (s,2H).

Provenance & Evidence