Octahydroindolizin-7-one → HCID 53944409, compound

Participants

Reaction Steps

A mixture of 5-hydroxybenzyl-1H-indole (3.69 g, 16.5 mmol) and 7-octahydroindolizinone (2.98 g, 21.5 mmol) in methanolic potassium hydroxide (10% potassium hydroxide in methanol, 50 ml) was heated to reflux for 3.5 hours. The reaction was diluted with water and the precipitate was collected by filtration. The filter cake was triturated with hot diethyl ether and filtered. The filter cake was recrystallized from methanol and dried to give 1.45 g of tan flakes. (25.8%).

Provenance & Evidence