5-Fluoroindole → HCID 9837987, compound

HRID 363328Notes

Reaction equation

HRID 363328 reaction equation
[F:1][C:2]1[CH:3]=[C:4]2[C:8](=[CH:9][CH:10]=1)[NH:7][CH:6]=[CH:5]2.[CH:11]1[C:19]2[N:14]([CH:15]=[CH:16][C:17](=O)[CH:18]=2)[CH2:13][CH:12]=1>>[CH2:11]1[CH:19]2[N:14]([CH2:15][CH:16]=[C:17]([C:5]3[C:4]4[C:8](=[CH:9][CH:10]=[C:2]([F:1])[CH:3]=4)[NH:7][CH:6]=3)[CH2:18]2)[CH2:13][CH2:12]1

Participants

3

Reactant 2

HCID 678615-FluoroindoleHCID 69592000HCID 69592000, compound

Product 1

HCID 9837987HCID 9837987, compound

Procedure

The 5-fluoro-1H-indole (910 mg, 6.7 mmol) and 7-indolizinone (1.40 g, 10.1 mmol) were converted to product by the procedure of Example 2 to give 1.22 g. (70.9%).

Workup

  1. customto give 1.22 g

Sources & evidence

ORD record
ord-bbef89b4f0f143cc844bb77a8de9e34f
Source dataset
uspto-grants-1999_02
Patent number
US05874427

Reaction notes

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