HCID 67570742, compound → HCID 67570746, compound

HRID 363330Notes

Reaction equation

HRID 363330 reaction equation
[F:1][C:2]1[CH:19]=[CH:18][C:5]([C:6]([N:8]2[C:16]3[C:11](=[CH:12][C:13]([NH2:17])=[CH:14][CH:15]=3)[CH:10]=[CH:9]2)=[O:7])=[CH:4][CH:3]=1.[CH:20]1[C:28]2[N:23]([CH:24]=[CH:25][C:26](=O)[CH:27]=2)[CH2:22][CH:21]=1>>[F:1][C:2]1[CH:19]=[CH:18][C:5]([C:6]([N:8]2[C:16]3[C:11](=[CH:12][C:13]([NH2:17])=[CH:14][CH:15]=3)[C:10]([C:26]3[CH2:27][CH:28]4[N:23]([CH2:22][CH2:21][CH2:20]4)[CH2:24][CH:25]=3)=[CH:9]2)=[O:7])=[CH:4][CH:3]=1

Participants

3

Reactant 2

HCID 67570742HCID 67570742, compoundHCID 69592000HCID 69592000, compound

Product 1

HCID 67570746HCID 67570746, compound

Procedure

The N-(4-fluorobenzoyl)-5-amino-1H-indole (813 mg, 3.20 mmol) and the 7-indolizinone (560 mg, 4.00 mmol) were converted to product by the procedure of Example 2 to give 818 mg. (68%).

Workup

  1. customto give 818 mg

Sources & evidence

ORD record
ord-8c121e082c0a4646b01837c3073f39c7
Source dataset
uspto-grants-1999_02
Patent number
US05874427

Reaction notes

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