HCID 67570928, compound → HCID 67570708, compound

HRID 363331Notes

Reaction equation

HRID 363331 reaction equation
[CH3:1][S:2]([N:5]1[C:13]2[C:8](=[CH:9][C:10]([NH2:14])=[CH:11][CH:12]=2)[CH:7]=[CH:6]1)(=[O:4])=[O:3].[CH:15]1[C:23]2[N:18]([CH:19]=[CH:20][C:21](=O)[CH:22]=2)[CH2:17][CH:16]=1>>[CH3:1][S:2]([N:5]1[C:13]2[C:8](=[CH:9][C:10]([NH2:14])=[CH:11][CH:12]=2)[C:7]([C:21]2[CH2:22][CH:23]3[N:18]([CH2:17][CH2:16][CH2:15]3)[CH2:19][CH:20]=2)=[CH:6]1)(=[O:4])=[O:3]

Participants

3

Reactant 2

HCID 67570928HCID 67570928, compoundHCID 69592000HCID 69592000, compound

Product 1

HCID 67570708HCID 67570708, compound

Procedure

The N-(methanesulfonyl)-5-amino-1H-indole (1.06 g, 5.00 mmol) and the 7-indolizinone (900 mg, 6.50 mmol) were converted to product by the procedure of Example 2 to give 807 mg. (48.7%).

Workup

  1. customto give 807 mg

Sources & evidence

ORD record
ord-ff34df22225b48158c35008b271d056d
Source dataset
uspto-grants-1999_02
Patent number
US05874427

Reaction notes

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