Acetyl chloride → HCID 67675657, compound

HRID 363338Notes

Reaction equation

[NH2:1][C:2]1[N:7]=[C:6]2[C:8]([C:11]3[CH2:19][CH:18]4[N:14]([CH2:15][CH2:16][CH2:17]4)[CH2:13][CH:12]=3)=[CH:9][NH:10][C:5]2=[CH:4][CH:3]=1.[C:20](Cl)(=[O:22])[CH3:21]>>[C:20]([N:10]1[C:5]2[C:6](=[N:7][C:2]([NH2:1])=[CH:3][CH:4]=2)[C:8]([C:11]2[CH2:19][CH:18]3[N:14]([CH2:15][CH2:16][CH2:17]3)[CH2:13][CH:12]=2)=[CH:9]1)(=[O:22])[CH3:21]

Participants

Reactant 2

HCID 6367Acetyl chloride

HCID 54097799HCID 54097799, compound

Product 1

HCID 67675657HCID 67675657, compoundYield 73%

Procedure

Beginning with 0.10 gm (0.39 mMol) 5-amino-3-(1,2,3,4,5,8-hexahydroindolizin-7-yl)pyrrolo[3,2-b]pyridine and 0.35 μL (0.47 mMol) acetyl chloride, 0.084 gm (73%) of the title compound were recovered by the procedure of Example 19.

Sources & evidence

ORD record: ord-56f77969387b41439bfbaf8fd62d7b99
Source dataset: uspto-grants-1999_02
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US05874427

Reaction notes

Loading…