HuagongsheHuagongshe Chemistry Print Report · For research reference only
O-Phenylenediamine → 2-[4-[3-(1-pyrrolidinyl)propoxy]phenyl]-1H-benzimidazole
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | O-Phenylenediamine | HCID 7243 | — |
| Reactant | 4-(3-Pyrrolidin-1-ylpropoxy)benzaldehyde | HCID 11651573 | — |
| Reactant | Sodium Bisulfite | HCID 23665763 | — |
| Solvent | Methanol | HCID 887 | — |
| Product | 2-[4-[3-(1-pyrrolidinyl)propoxy]phenyl]-1H-benzimidazole | HCID 15291582 | 34% |
Reaction Steps
1,2-Diaminobenzene (4.65 g), 4-[3-(1-pyrrolidinyl)propoxy]benzaldehyde (Step B) (10.0 g) and sodium bisulfite (4.60 g) are stirred at reflux in methanol (300 mL) for 14 hours. The mixture is filtered and evaporated. The residue is recrystallized from hot ethyl acetate/ethanol to give 4.68 g of the title compound as a yellow solid.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05414010 |
| Source dataset | uspto-grants-1995_05 |
| ORD ID | ord-8821c957c0154351b1980809148be464 |
| Source note | uspto-grants-1995_05 |