HuagongsheHuagongshe Chemistry Print Report · For research reference only
Adenine → 9-Ethyladenine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Adenine | HCID 190 | — |
| Reactant | Dimethylformamide | HCID 6228 | — |
| Reactant | Tetrahydrofuran | HCID 8028 | — |
| Product | 9-Ethyladenine | HCID 7 | 43% |
Reaction Steps
Coupling of 2b with adenine in THF in the presence of Ph3P and DEAD formed the desired N9 -substituted derivative 1a in only 5% yield. The low yield may be due to the insolubility of adenine in THF. After replacement of THF with DMF, compound 1a was produced in 43% yield without any detection of the N7 - derivative or the N9 -ethyladenine.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05874577 |
| Source dataset | uspto-grants-1999_02 |
| ORD ID | ord-b85d1adf9ae14e23bfa2a836e6a9cbab |
| Source note | uspto-grants-1999_02 |