Triethylamine → p-Toluenesulfonic acid

Participants

Reaction Conditions

Reaction Steps

A mixture of 5.00 g of 5,6,7,7a-tetrahydro-4H-thieno[3,2 -c]pyridin-2-one-p-toluenesulfonate, 2.47 g of tert-butyl-dimethylchlorosilane, 1.66 g of triethylamine and 15 ml of methylene chloride was stirred at room temperature (20° C.) for 3 hours. The produced 2-(tert-butyldimethylsilyloxy)-4,5,6,7-tetrahydrothieno[3,2-c]pyridine.p-toluenesulfonate was not isolated, 2.40 g of 2-chlorobenzyl chloride and 3.02 g of triethylamine were added thereto, and the mixture was allowed to react under stirring at 40° C. for 8 hours.

Provenance & Evidence