HuagongsheHuagongshe Chemistry Print Report · For research reference only
Hydrochloric Acid → 2,4-Diaminoquinazoline-6-carbonitrile
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | Potassium Cyanide | HCID 9032 | — |
| Reactant | 2,4,6-Triaminoquinazoline | HCID 292661 | — |
| Reactant | Sodium Nitrite | HCID 23668193 | — |
| Catalyst | Copper sulfate pentahydrate | HCID 24463 | — |
| Solvent | Water | HCID 962 | — |
| Product | 2,4-Diaminoquinazoline-6-carbonitrile | HCID 282699 | — |
Reaction Steps
The 2,4,6-triaminoquinazoline derivatives described above may then optionally be treated with 2N hydrochloric acid, sodium nitrite, potassium cyanide, and copper(II) sulfate pentahydrate in water, affording the corresponding 2,4-diamino-6-cyanoquinazoline, for example, 2,4-diamino-6-cyano-5-methylquinazoline. Step A of Example 14 describes in detail this step in the reaction sequence.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05874579 |
| Source dataset | uspto-grants-1999_02 |
| ORD ID | ord-7277bc0011fe405dad56b577b77780ee |
| Source note | uspto-grants-1999_02 |