Benzyl bromoacetate → HCID 57313411, compound

HRID 363870Notes

Reaction equation

HRID 363870 reaction equation
[CH3:1][O:2][C:3](=[O:25])[CH2:4][N:5]1[C:11]2[CH:12]=[CH:13][CH:14]=[CH:15][C:10]=2[NH:9][CH2:8][C@H:7]([NH:16][C:17]([O:19][C:20]([CH3:23])([CH3:22])[CH3:21])=[O:18])[C:6]1=[O:24].BrCC(OC[C:32]1[CH:37]=[CH:36][CH:35]=[CH:34][CH:33]=1)=O>>[CH2:1]([O:2][C:3](=[O:25])[CH2:4][N:5]1[C:11]2[CH:12]=[CH:13][CH:14]=[CH:15][C:10]=2[NH:9][CH2:8][C@H:7]([NH:16][C:17]([O:19][C:20]([CH3:22])([CH3:21])[CH3:23])=[O:18])[C:6]1=[O:24])[C:32]1[CH:37]=[CH:36][CH:35]=[CH:34][CH:33]=1

Participants

3

Reactant 2

HCID 62576Benzyl bromoacetateHCID 54305289(3S)-2-Oxo-3-tert-butoxycarbonylamino-2,3,4,5-tetrahydro-1H-1,5-benzodiazepine-1-acetic acid methyl ester

Product 1

HCID 57313411HCID 57313411, compound

Procedure

Prepared by a similar method described for the preparation of 600a (Step D), except benzyl bromoacetate was used instead of methyl bromoacetate to give 600b in quantitative yield.

Workup

  1. customPrepared by a similar method

Sources & evidence

ORD record
ord-bff8448d5dbc42c8b731d1f65bf8eb90
Source dataset
uspto-grants-1999_02
Patent number
US05874424

Reaction notes

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