Thiourea → HCID 178441224, compound

HRID 364005Notes

Reaction equation

HRID 364005 reaction equation
NC(N)=[S:3].Cl[C:6]1[N:7]2[C:11]([N:12]=[C:13]([C:15]([CH3:18])([CH3:17])[CH3:16])[CH:14]=1)=[N:10][CH:9]=[N:8]2>C(O)C>[SH:3][C:6]1[N:7]2[C:11]([N:12]=[C:13]([C:15]([CH3:18])([CH3:17])[CH3:16])[CH:14]=1)=[N:10][CH:9]=[N:8]2

Participants

4

Reactant 2

HCID 2723790ThioureaHCID 167682715-tert-butyl-7-chloro[1,2,4]triazolo[1,5-a]pyrimidine

Product 1

HCID 178441224HCID 178441224, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

8.7 g of thiourea was dissolved in 150 ml of ethanol and thereto was added 4-chloro-6-t-butyl-1,3,3a,7-tetraazaindene. The resulting mixture was refluxed for 1.5 hours over a water bath. At the conclusion of the refluxing the product precipitated as crystals. Upon distilling off the ethanol, needle crystals were obtained. Repeated recrystallization from 1.8 l of ethanol gave 7.4 g of intended compound having a melting point of 285° to 286° C.

Workup

  1. temperatureThe resulting mixture was refluxed for 1.5 hours over a water bath
  2. customAt the conclusion of the refluxing the product precipitated as crystals
  3. distillationUpon distilling off the ethanol
  4. customneedle crystals were obtained
  5. customrecrystallization from 1.8 l of ethanol

Sources & evidence

ORD record
ord-2d77b78a543a4aa98b9ce6b40c389e06
Source dataset
uspto-grants-1986_08
Patent number
US04604339

Reaction notes

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