2-Benzyl-7-methyl-2,7-diazaspiro[4.4]nonane Dihydrochloride → 2-Methyl-2,7-diazaspiro[4.4]nonane dihydrochloride

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Reaction Steps

A solution of 2-methyl-7-(phenylmethyl)-2,7-diazaspiro-[4.4]nonane dihydrochloride in 150 ml of methanol with 1.0 g 20% palladium on carbon catalyst was hydrogenated at 50 psi for two days. After filtration, the filtrate was concentrated to a thick syrup which crystallized on addition of acetonitrile to give 11.50 g of 2-Methyl-2,7diazaspiro[4.4]nonane dihydrochloride, softened at 164° C. and melted at 168°-170° C. EXAMPLE I

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