HCID 131714800, compound → HCID 18603968, compound

Participants

Reaction Steps

The ester product from part (c) is taken up into 125 ml. of methanol containing 400 mg. of palladium on carbon catalyst (10%) and stirred under positive hydrogen pressure for 20 hours. The reaction mixture is filtered and concentrated to dryness in vacuo. The crude product is purified chromatographically to yield (±)-1-[[[3-(benzoylamino)-4-(4-hydroxyphenyl)-2-hydroxybutyl]methylamino]carbonyl]-L-proline.

Provenance & Evidence