Hydrochloric Acid → HCID 131714803, compound

Participants

Reaction Steps

The ester product from part (g) is taken into 40 ml. of 95% ethanol, 0.584 ml. of 1N hydrochloric acid, and 50 mg. of palladium on carbon catalyst (10%). The mixture is stirred under hydrogen pressure for 24 hours. The reaction mixture is then filtered and concentrated to dryness in vacuo. The crude product is purified on an LH-20 column in water to yield 1-[[(4-aminobutyl)[3-(benzoylamino)-2-hydroxy-4-phenylbutyl]amino]carbonyl]-L-proline, monohydrochloride.

Provenance & Evidence