3-Pyridinemethanol → HCID 56623210, compound

Participants

Reaction Steps

1-[[[(3S)-3-(Benzoylamino)-2-hydroxy-4-phenylbutyl]methylamino]carbonyl]-L-proline (isomer A), 4-dimethylamino pyridine, 3-pyridinylcarbinol and dicyclohexylcarbodiimide are taken up into tetrahydrofuran with stirring in an ice bath. The reaction proceeds overnight at room temperature. The dicyclohexylurea is filtered off and the filtrate is concentrated to dryness. The crude product is chromatographed on silica gel to give 1-[[[(3S)-3-(benzoylamino)-2-hydroxy-4-phenylbutyl]methylamino]carbonyl]-L-proline, 3-pyridinylmethyl ester (isomer A).

Provenance & Evidence