3-(7,8-dimethoxy-1-benzyl-1,3,4,5-tetrahydro-2H-1,3-benzdiazepin-2-on-3-yl)-1-chloropropane → N-[3-(7,8-Dimethoxy-1-benzyl-1,3,4,5-tetrahydro-2H-1,3-benzdiazepin-2-on-3-yl)-propyl]-2-(4-amino-3,5-dichlorophenylamino)-ethylamine

HRID 364118Notes

Reaction equation

HRID 364118 reaction equation
[CH3:1][O:2][C:3]1[C:4]([O:26][CH3:27])=[CH:5][C:6]2[N:12]([CH2:13][C:14]3[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=3)[C:11](=[O:20])[N:10]([CH2:21][CH2:22][CH2:23]Cl)[CH2:9][CH2:8][C:7]=2[CH:25]=1.[NH2:28][C:29]1[C:34]([Cl:35])=[CH:33][C:32]([NH:36][CH2:37][CH2:38][NH2:39])=[CH:31][C:30]=1[Cl:40]>>[CH3:1][O:2][C:3]1[C:4]([O:26][CH3:27])=[CH:5][C:6]2[N:12]([CH2:13][C:14]3[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=3)[C:11](=[O:20])[N:10]([CH2:21][CH2:22][CH2:23][NH:39][CH2:38][CH2:37][NH:36][C:32]3[CH:31]=[C:30]([Cl:40])[C:29]([NH2:28])=[C:34]([Cl:35])[CH:33]=3)[CH2:9][CH2:8][C:7]=2[CH:25]=1

Participants

3

Reactant 2

HCID 202401013-(7,8-dimethoxy-1-benzyl-1,3,4,5-tetrahydro-2H-1,3-benzdiazepin-2-on-3-yl)-1-chloropropaneHCID 202401212-(4-Amino-3,5-dichlorophenylamino)-ethylamine

Product 1

HCID 20240122N-[3-(7,8-Dimethoxy-1-benzyl-1,3,4,5-tetrahydro-2H-1,3-benzdiazepin-2-on-3-yl)-propyl]-2-(4-amino-3,5-dichlorophenylamino)-ethylamine

Procedure

The title compound is prepared from 3-(7,8-dimethoxy-1-benzyl-1,3,4,5-tetrahydro-2H-1,3-benzdiazepin-2-on-3-yl)-1-chloropropane and 2-(4-amino-3,5-dichloro-phenylamino)-ethylamine analogously to Example 6.

Sources & evidence

ORD record
ord-09bb29577dd549b98b81ac95e59c8fb1
Source dataset
uspto-grants-1986_08
Patent number
US04604389

Reaction notes

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