HCID 86740935, compound → HCID 20240276, compound

HRID 364129Notes

Reaction equation

HRID 364129 reaction equation
C([N:8]1[CH2:13][CH2:12][CH2:11][C@@H:10]2[C:14]3[CH:21]=[C:20]([O:22][CH3:23])[CH:19]=[CH:18][C:15]=3[O:16][CH2:17][C@@H:9]12)C1C=CC=CC=1.[H][H]>C(O)C.[Pd]>[CH3:23][O:22][C:20]1[CH:19]=[CH:18][C:15]2[O:16][CH2:17][CH:9]3[NH:8][CH2:13][CH2:12][CH2:11][CH:10]3[C:14]=2[CH:21]=1

Participants

5

Reactant 2

HCID 86740935HCID 86740935, compoundHCID 178418361HCID 178418361, compound

Product 1

HCID 20240276HCID 20240276, compound

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 702EthanolSolvent

Procedure

A solution of 1.5 g of trans-4-benzyl-9-methoxy-1,2,3,4a,5,10b-hexahydro-4H-[1]-benzopyrano[3,4-b]pyridine in 30 ml of ethanol is hydrogenated at 300 kPa pressure in the presence of 0.5 g of 10% palladium on charcoal until one mole of hydrogen is consumed. The reaction mixture is filtered, evaporated to dryness to give 9-methoxy-1,2,3,4a,5,10b-hexahydro-4H-[1]-benzopyrano[3,4-b]pyridine.

Workup

  1. customis consumed
  2. filtrationThe reaction mixture is filtered
  3. customevaporated to dryness

Sources & evidence

ORD record
ord-89c45a033211494a90a05f8da595000c
Source dataset
uspto-grants-1986_08
Patent number
US04604397

Reaction notes

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