Methanol → HCID 131714807, compound

Participants

Reaction Steps

To a mixture of 2.45 g of N-[2-[2-(diethylamino)-ethyl]-9-hydroxy-2H-[1]benzopyrano[4,3,2-cd]indazol-5-yl]-2-[[2-(phenylmethoxy)ethyl](phenylmethyl)amino]acetamide in 80 ml of dry tetrahydrofuran under argon was added 40 ml of 1M solution of borane tetrahydrofuran complex in tetrahydrofuran. After 24 hours at 50° C., an additional 3 ml of borane tetrahydrofuran complex was added and the reaction continued for another three hours at 50° C. The mixture was poured into 150 ml of methanol, heated under reflux overnight, evaporated to dryness, and the residue of crystallized from diethyl ether to afford 1.36 g of 2-[2-diethylamino)ethyl]-5-[[2-(phenylmethoxy)ethyl](phenylmethyl)amino]ethyl]amino]-2H-[1]benzopyrano[4,3,2-cd]indazol-9-ol.

Provenance & Evidence