2-(5-Chloro-2-nitrophenoxy)-5-methoxybenzoic acid → 1-Chloro-7-methoxy-4-nitro-9H-xanthen-9-one

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Reaction Conditions

Reaction Steps

2-(5-Chloro-2-nitrophenoxy)-5-methoxybenzoic acid, 50 g, was added to 400 g of polyphosphoric acid, and the mixture stirred at 110° C. for 24 hours. The mixture was poured into 2 liters of water, and the resulting precipitate filtered to afford a light green solid. Recrystallization from dimethylformamide gave the title compound as green needles, mo 249°-251° C.

Provenance & Evidence