Formic Acid → 3-(3,4-Dimethoxyphenyl)propionic acid

Participants

Reaction Conditions

Reaction Steps

After adding 2.1 ml of the mixture of formic acid and triethylamine prepared as described in Example 1 to 20 ml of acetonitrile, 3.60 g (0.025 mol) of Meldrum's acid and 4.15 g (0.025 mol) of veratraldehyde were added to the reaction mixture. After heating same to its boiling point (82° C.) within 30 minutes and refluxing it for 4 hours, the acetonitrile was evaporated under reduced pressure, then the method of Example 1 was followed to give 3.6 g of a product, m.p.: 91°-93.5° C., which was recrystallized from aqueous methanol of 50% by volume.

Provenance & Evidence