2-Bromoethylamine hydrobromide → HCID 131714814, compound

HRID 364207Notes

Reaction equation

HRID 364207 reaction equation
[NH2:1][C:2]1[CH:10]=[C:9]([O:11][CH3:12])[C:8]2[N:7]([CH2:13][CH2:14][N:15]([CH2:18][CH3:19])[CH2:16][CH3:17])[N:6]=[C:5]3[C:20]4[CH:26]=[C:25]([O:27][CH3:28])[CH:24]=[CH:23][C:21]=4[S:22][C:3]=1[C:4]=23.Br.[Br:30][CH2:31][CH2:32][NH2:33]>CCO>[BrH:30].[CH2:16]([N:15]([CH2:18][CH3:19])[CH2:14][CH2:13][N:7]1[C:8]2[C:9]([O:11][CH3:12])=[CH:10][C:2]([NH:1][CH2:31][CH2:32][NH2:33])=[C:3]3[S:22][C:21]4[CH:23]=[CH:24][C:25]([O:27][CH3:28])=[CH:26][C:20]=4[C:5]([C:4]=23)=[N:6]1)[CH3:17]

Participants

4

Reactant 2

HCID 27742172-Bromoethylamine hydrobromideHCID 20240182HCID 20240182, compound

Product 1

HCID 131714814HCID 131714814, compoundYield 36.3%

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

Reaction of a solution of 3.6 g (0.0095 mol) of 5-amino-N,N-diethyl-3,9-dimethoxy-2H[1]benzothiopyrano[4,3,2-cd]indazole-2-ethanamine and 5.8 g (0.0283 mol) of 2-bromoethylamine, hydrobromide, in 30 ml of EtOH as described in Example 38 gave 1.8 g of product.

Sources & evidence

ORD record
ord-9138b8415c9b46cc8258bd0e783a232a
Source dataset
uspto-grants-1986_08
Patent number
US04604390

Reaction notes

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