Sodium Methoxide → HCID 13377361, compound

HRID 364238Notes

Reaction equation

HRID 364238 reaction equation
[CH3:1][O-:2].[Na+].Cl[C:5]1[N:10]2[C:11]([CH:14]([CH3:16])[CH3:15])=[N:12][CH:13]=[C:9]2[CH:8]=[C:7]([Cl:17])[N:6]=1>>[Cl:17][C:7]1[N:6]=[C:5]([O:2][CH3:1])[N:10]2[C:11]([CH:14]([CH3:16])[CH3:15])=[N:12][CH:13]=[C:9]2[CH:8]=1

Participants

3

Reactant 2

HCID 10942334Sodium MethoxideHCID 13377343HCID 13377343, compound

Product 1

HCID 13377361HCID 13377361, compound

Procedure

Using the method of Example 48, sodium methoxide was reacted with 5,7-dichloro-3-isopropylimidazo[1,5-c]pyrimidine (from Example 37) to provide 7-chloro-3-isopropyl-5-methoxyimidazo[1,5-c]pyrimidine. This free base was a white solid which was converted into its white solid dihydrogen sulfate salt, m.p. 155° C. (dec.). Analysis: Calculated for C10H12ClN3O.H2SO4 : %C, 37.1; %H, 4.4; %N, 13.0; Found; %C, 36.7; %H, 4.2; %N, 12.9.

Sources & evidence

ORD record
ord-5e5c215fdec54ee59d41edd51784bc3a
Source dataset
uspto-grants-1986_08
Patent number
US04604466

Reaction notes

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