HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 36424Generated: October 30, 2026
Formic Acid → 3-(3,4-Dimethoxyphenyl)propionic acid
https://huagongshe.com/reaction/36424
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Formic Acid | HCID 284 | — |
| Reactant | Veratraldehyde | HCID 8419 | — |
| Reactant | N-Ethylpiperidine | HCID 13007 | — |
| Reactant | 2,2-Dimethyl-1,3-dioxane-4,6-dione | HCID 16249 | — |
| Product | 3-(3,4-Dimethoxyphenyl)propionic acid | HCID 75019 | — |
Reaction Steps
After dropwise adding 27.2 g (33.1 ml, 0.24 mol) of 1-ethylpiperidine to 27.6 g (22.6 ml, 0.6 mol) of formic acid under stirring, 7.2 g (0.05 mol) of Meldrum's acid and 8.3 g (0.05 mol) of veratraldehyde were added to the solution which was then heated to 95° C. during 1 hour and reacted at the same temperature for 2 hours. Subsequently the method of Example 1 was followed.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US05414108 |
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| Source dataset | uspto-grants-1995_05 |
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| ORD ID | ord-98c9c684f5b74367beaeb73d15866907 |
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| Source note | uspto-grants-1995_05 |
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