Isopropylamine → 3-Isopropylamino-1,2-propanediol

HRID 364255Notes

Reaction equation

HRID 364255 reaction equation
[CH2:1]1[O:3][CH:2]1[CH2:4][OH:5].[CH:6]([NH2:9])([CH3:8])[CH3:7]>>[CH:6]([NH:9][CH2:1][CH:2]([OH:3])[CH2:4][OH:5])([CH3:8])[CH3:7]

Participants

3

Reactant 2

HCID 6363IsopropylamineHCID 11164Glycidol

Product 1

HCID 1108573-Isopropylamino-1,2-propanediolYield 79.6%

Procedure

A mixture of 37 g (0.5 mole) of glycidol and 35.4 g (0.6 mole) of isopropylamine was stirred at 25° overnight. Excess isopropylamine was evaporated in vacuo and the mixture was distilled to give 53 g of product: b.p. 80° C./0.1 mm Hg. The NMR and IR spectra were consistent with the assigned structure and the elemental analysis was consistent with the empirical formula C6H15O2N.

Workup

  1. customExcess isopropylamine was evaporated in vacuo
  2. distillationthe mixture was distilled

Sources & evidence

ORD record
ord-1e4314bb843c4dc289ec29540a841a7d
Source dataset
uspto-grants-1986_08
Patent number
US04604481

Reaction notes

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