HuagongsheHuagongshe Chemistry Print Report · For research reference only
Acetonitrile → 4-[2-(2,2,2-Trifluoroethyl)guanidino]-2-[2-(2-nitro-3-methylguanidino)ethylthiomethyl]pyrimidine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Acetonitrile | HCID 6342 | — |
| Reactant | 4-[2-(2,2,2-Trifluoroethyl)guanidino]-2-(2-aminoethyl)thiomethylpyrimidine | HCID 21298720 | — |
| Reactant | N-Nitro-S-methylisothiourea | HCID 135927615 | — |
| Product | 4-[2-(2,2,2-Trifluoroethyl)guanidino]-2-[2-(2-nitro-3-methylguanidino)ethylthiomethyl]pyrimidine | HCID 136408877 | — |
Reaction Steps
1-Nitro-2-methylisothiourea (0.135 g.) was added to a stirred solution of 4-[2-(2,2,2-trifluoroethyl)guanidino]-2-[(2-aminoethyl)thiomethyl]pyrimidine (0.31 g.) in acetonitrile (5 ml.) and the suspension stirred at room temperature for 2 hours. The insoluble material was collected to give 4-[2-(2,2,2-trifluoroethyl)guanidino]-2-[2-(2-nitro-3-methylguanidino)ethylthiomethyl]pyrimidine (0.35 g.) m.p. 199°-200° (decomp.)
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04604465 |
| Source dataset | uspto-grants-1986_08 |
| ORD ID | ord-a3c6af2a34354e2d9ee9223e671e229b |
| Source note | uspto-grants-1986_08 |