HuagongsheHuagongshe Chemistry Print Report · For research reference only
1-Methylthio-1-methylamino-2-nitroethylene → 1-(2-[4-(2-[2,2,2-Trifluoroethyl]guanidino)pyrimid-2-yl-methylthio]ethylamino)-1-methylamino-2-nitroethylene
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 1-Methylthio-1-methylamino-2-nitroethylene | HCID 123549 | — |
| Reactant | 4-[2-(2,2,2-Trifluoroethyl)guanidino]-2-(2-aminoethyl)thiomethylpyrimidine | HCID 21298720 | — |
| Solvent | Acetonitrile | HCID 6342 | — |
| Product | 1-(2-[4-(2-[2,2,2-Trifluoroethyl]guanidino)pyrimid-2-yl-methylthio]ethylamino)-1-methylamino-2-nitroethylene | HCID 70418646 | 63.3% |
Reaction Steps
A mixture of 4-[2-(2,2,2,-trifluoroethyl)guanidino]-2-[(2-aminoethyl)thiomethyl]pyrimidine (0.31 g.) 1-methylamino-1-methylthio-2-nitroethylene (0.15 g.) and acetonitrile (5 ml.) was heated under reflux for 6 hours and then left at room temperature for 18 hours. The yellow crystalline precipitate was collected to give 1-(2-[4-(2-[2,2,2-trifluoroethyl]guanidino)pyrimid-2-yl-methylthio]ethylamino)-1-methylamino-2-nitroethylene (0.26 g.), m.p. 154°-157° after recrystallisation from ethanol.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04604465 |
| Source dataset | uspto-grants-1986_08 |
| ORD ID | ord-8aabd251912646068457d13c08ce387d |
| Source note | uspto-grants-1986_08 |