HuagongsheHuagongshe Chemistry Print Report · For research reference only
2-(Methylthio)pyrimidin-4-amine → 4-[3-(2,2,2-Trifluoroethyl)thioureido]-2-methylthiopyrimidine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2-(Methylthio)pyrimidin-4-amine | HCID 259225 | — |
| Reactant | 1,1,1-Trifluoro-2-isothiocyanatoethane | HCID 13883777 | — |
| Solvent | Acetonitrile | HCID 6342 | — |
| Product | 4-[3-(2,2,2-Trifluoroethyl)thioureido]-2-methylthiopyrimidine | HCID 54247278 | 51.2% |
Reaction Steps
A mixture of 4-amino-2-methylthiopyrimidine (2.1 g.), 2,2,2-trifluoroethylisothiocyanate (2.8 g.) and acetonitrile (5 ml.) was stirred at 70° for 72 hours and then cooled, and the solid that crystallised was collected to give 4-[3-(2,2,2-trifluoroethyl)thioureido]-2-methylthiopyrimidine (2.15 g.) which was used without further purification.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04604465 |
| Source dataset | uspto-grants-1986_08 |
| ORD ID | ord-4bf27e3c090b4dde93c8fd32605f7e0b |
| Source note | uspto-grants-1986_08 |