HuagongsheHuagongshe Chemistry Print Report · For research reference only
Dimethylformamide → 4-[3-(2,2,2-Trifluoroethyl)thioureido]-2-(2-phthalimidoethylthio)pyrimidine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Dimethylformamide | HCID 6228 | — |
| Reactant | 1,1,1-Trifluoro-2-isothiocyanatoethane | HCID 13883777 | — |
| Reactant | 4-Amino-2-(2-phthalimidoethylthio)pyrimidine | HCID 21298737 | — |
| Solvent | Acetonitrile | HCID 6342 | — |
| Product | 4-[3-(2,2,2-Trifluoroethyl)thioureido]-2-(2-phthalimidoethylthio)pyrimidine | HCID 53895213 | 59.5% |
Reaction Steps
A mixture of 4-amino-2-(2-phthalimidoethylthio)pyrimidine (0.8 g.), 2,2,2-trifluoroethylisothiocyanate (0.56 g.) and dimethyl formamide (2 ml.) was stirred at 70° for 72 hours. The mixture was cooled, diluted with acetonitrile and filtered to give 4-[3-(2,2,2-trifluoroethyl)thioureido]-2-(2-phthalimidoethylthio)pyrimidine (0.7 g.), m.p. 238°-241°.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04604465 |
| Source dataset | uspto-grants-1986_08 |
| ORD ID | ord-919730832d234cdab4004757a61fcf3f |
| Source note | uspto-grants-1986_08 |