HuagongsheHuagongshe Chemistry Print Report · For research reference only
Ammonia → 4-[2-(2,2,2-Trifluoroethyl)guanidino]-2-(2-phthalimidoethylthio)pyrimidine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Ammonia | HCID 222 | — |
| Reactant | 4-[3-(2,2,2-Trifluoroethyl)thioureido]-2-(2-phthalimidoethylthio)pyrimidine | HCID 53895213 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | 4-[2-(2,2,2-Trifluoroethyl)guanidino]-2-(2-phthalimidoethylthio)pyrimidine | HCID 21298730 | — |
Reaction Steps
A mixture of 4-[3-(2,2,2-trifluoroethyl)thioureido]-2-(2-phthalimidoethylthio)pyrimidine (0.65 g.), dimethylformamide (10 ml.), ethanolic ammonia solution (5 ml.) and yellow mercuric oxide was stirred at room temperature for 4 hours. The mixture was filtered and the filtrate evaporated to dryness to give 4-[2-(2,2,2-trifluoroethyl)guanidino]-2-(2-phthalimidoethylthio)-pyrimidine (0.62 g.), m.p. 192°-195°.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04604465 |
| Source dataset | uspto-grants-1986_08 |
| ORD ID | ord-f661f8a648f643bb9f4839bb2d9996f6 |
| Source note | uspto-grants-1986_08 |